Tuesday, January 28, 2020
Management Essay 1) What forces for change are evident at the Oconomo plant? (5) The forces for change that are evident at the Oconomo plant are the callenges dealing with high labor cost. As a result Lamprey is deciding to lower wages from $16 to $1.60 per hour. Also the union and Oconomo are disagreeing with this new change taking place with the wages. 2) Which of the forces in force-field analysis do you think would be more powerful than the other in this situation? Between the two forces I think the Driving Force would be more powerful than the other in this situation. The greatest force that drives the company to expect change is that itÃ¢â¬â¢s operating at a high cost and instead of giving returns itÃ¢â¬â¢s giving out loses. As a result, the aim of the company is to make changes so that it can appreciate profits in the future. In additional to there being high cost the thing that needs to be understood is that in order for the company to meet its operations it must realize some of the returns from what it has invested. Having invested in the company the managers and shareholders should expect that the company is going to provide sufficient returns which will be shared and at the same time enable the company to stay in the market. There also exist the risks of the competitors who are in the market currently. For the company to make it in the market, it must change its working conditions so that they fit with the current market situation. Another problem is the workers point of refusing to cooperate. The company is planning to reduce the amount of pay itÃ¢â¬â¢s going to provide to its workers with a significant drop. This is a great problem which workers are not ready to accept the desired change of the company. Another force for change is that competitors are in the market and of late they have threatened the company from the services and products that they are providing to the society. Quality is one thing that the company should look at so as to retain its market segment else the upcoming companies will outperform the company. 3) What is the primary type of change needed Ã¢â¬â changing Ã¢â¬Å"thingsÃ¢â¬ or changing the Ã¢â¬Å"people and cultureÃ¢â¬ ? The primary change that is appropriate at the moment is changing the people and their culture. The reason as to why changing people and culture is of importance to the company is that having changed people all other things will work accordingly. PeopleÃ¢â¬â¢s culture is of importance in the way the company operates simply because if the culture or people fit in the objectives of the company then all other things will be in place. People are the main target of any given business set up. This means that in changing anything that is in respect to the companyÃ¢â¬â¢s operations then the people and their culture is the initial thing that should be taken into consideration. Another thing is that having changed peopleÃ¢â¬â¢s perception competitors will have no say because you would have drove the attentions of the market to your operations. 4) What do you think is the underlying cause of the union leadersÃ¢â¬â¢ resistance to change? Union leaders are resistant to change due to a single reason which the company is reluctant to handle. The reason as to the resistance is that Oconomo plant has plans to provide workers with less wages which they feel they cant live within that budget. Looking at some companies which are emerging, union leaders are not ready to accept the change simply because those companies are giving out wages which are high and the quality of services and products that they have is almost outdoing the one Oconomo plant is providing. Jim has a hard time of convincing union leaders on what should be done. What he is supposed to do is to give union leaders the risk behind getting a new job if they lose the one they have. There are so many people in the town who are looking for job. Also, he should convince them to work as the negotiation is being carried out for a better change. There are benefits that workers get from the company and if they resign, such as medical and insurance benefits, then they will no longer get until they get another job.
Monday, January 20, 2020
The world that we understand is rapidly becoming a much smaller entity. Technology is rapidly bringing us to places we have never been before. Thanks to widespread globalization, and the explosive growth and use of the internet, people are uniting and communicating in ways never dreamed two decades past. While more developed countries are taking advantage of this new global village, less developed countries helplessly stay in their idle life rafts as the sharks of these new virtual communities circle round. In the dawn of time communication started with mediums such as facial expressions, groaning, and sometimes just whacking a member of your community in the head. Communications simplest form is essentially dying with the construction and use of this web of interweaving technology known as the internet. Unlike forms of communication of days long past , not everyone can get involved in this World Wide Web. The internet is a community that uses a simple non intentional form of segregation that limits the use of the internet to people who live in countries that have the ability to set up these online villages. The makings of this new virtual revolution is essentially separating people. In the article Social Policy for Cyberspace, Dale Spender argues how people are being rapidly separated into two groups: the Master Minds and those that are being kept in the dark. She also explains how the People in the real world are being divided up into the information-rich and the poor. (Spender, Composing Cyberspace, p 266.) Basically the people with access to a global village are moving forward and the people in underdeveloped countries are lying stagnant. Like myself, Spender believes strongly in the well being of Third World countri... ...ciety demands a world that must rapidly change and make life easier we will strive to achieve that level no matter what the task. Eventually everyone on this earth will be able to connect to create the ultimate utopian global village, but until then we must look to countries less fortunate than us and continue to try and industrialize them to bring them up to our cyber caliber before they are forgotten. Priority needs to be given to research and policies that actually examine and deal with the impact that the new technologies are having on human beings, globally, nationally and locally. (Spender, Composing Cyberspace, p 269.) Works Cited Holten, Richard. Composing Cyberspace: Identity, community, and knowledge, in the electronic age. United States: Mcgraw-hill companies inc. 1998. Spender, Dale. Composing Cyberspace; Social Policy for cyberspace. P. 266
Sunday, January 12, 2020
It is my fervent wish to attend the prestigious University of Pennsylvania School of Dental Medicine primarily because of the instant respect that a graduate of this 128 year old institution commands and also because I share the university and I share the same mission objectives and beliefs. I firmly believe that my goal of becoming and exceptional citizen who strives to offer the best available, affordable and even free dental services to those in need will be lent a guiding hand by the university. This is because just like the university, I believe that dentistry is a lifelong commitment that requires a lifetime of learning and discipline that will help me achieve my objective of providing a necessary dental care to the people who need it the most regardless of their status in life and financial capability. Achieving this will be possible for me because Penn Dental Medicine encourages their students to undertake dental researches and education that most often thrusts their students into the center of innovative and improved dental care methods. It is my hope that I will be given the chance to join the roster of students of Penn Dental Medicine who have gone on to become leaders in their chosen areas of dental specialization by attending regular classes in the atmosphere of the school that is conducive to students like me who strive for constant learning. Since Penn Dental Medicine encourages free expression, reasoned discourse, and diversity of ideas, I believe that I can only blossom and reach my full intellectual potential while attending this university because I will be allowed to explore my full potential not only as dental student and future dentist, but also as an individual whose rights are respected by the university as well.
Saturday, January 4, 2020
Sample details Pages: 5 Words: 1520 Downloads: 5 Date added: 2019/06/26 Category Biology Essay Level High school Tags: Stem Cell Essay Did you like this example? In this paper I will mainly focus on the effects of stem cell injections on skeletal muscle injures in mice, this is because those types of muscle injuries are extremely common. Skeletal muscle is a highly specialized tissue made up of non-dividing, multi-nucleated muscle fibers, which contract to generate force in a controlled and controlled manner,which account for up to half the mass of the human body. However, effective muscle function is both mechanically and energetically demanding, making this tissue particularly susceptible to damage. DonÃ¢â¬â¢t waste time! Our writers will create an original "Could Stem Cell Injections Heal Muscles?" essay for you Create order Such muscle damage may reduce mobility and contribute to metabolic. Skeletal muscle has a strong innate tissue damage repair capability. Despite the proficiency of this intrinsic repair capability, severe injuries resulting in a significant loss of muscle tissue overwhelm the innate repair process and require intervention in order to restore muscle function. Natural muscle damage repair is a step wise process requiring the coordinated activity of a number of cell types involving three healing steps: degeneration and inflammation, regeneration and fibrosis. There is a phase of myofiber degeneration immediately after injury that is initiated by the release of proteases into the tissue stroma; these proteases automatically digest myofibers and thereby release tissue debris along the injury zone. In addition, macrophages stimulate the paracrine release by T cells of cytokines and other chemotactic factors that can recruit progenitor and satellite cells with muscle regeneration capacity locally. While the degeneration phase is transient, the subsequent regeneration phase of myofibers is the first step in the long-term pattern of skeletal muscle injury. This phase may begin as early as 24 hours after injury, as evidenced by the cytokine-mediated induction of local satellite cells that previously lie dormant between the basal lamina and sarcolemma; however, the complete formation of new, centronucleated myofibers cannot be detected histologically until at least 3 5 days after injury. It is likely that the differentiation of satellite cells into myotubules and myofibers is a crucial event in the regeneration phase. To date, these progenitor cells are perhaps the best characterized and are often referred to as muscle stem cells because they favor myogenic lines. Fibrous tissue prevents the full recovery of the muscle and current therapies fail to achieve total recovery of the muscle. Gene and (or both) cell therapy are potential future treatments for serious muscle injuries. The properties of stem cells related to growth factors and /or cytokines can improve muscle healing and allow for long term recovery. Perhaps the biggest limitation for patients resulting from skeletal muscle injury pathophysiology is the formation of a dense fibrotic scar tissue. Clearly, fibrosis is caused by a deleterious increase in the cytokine growth factor (TGF)-B1 following injury. MDSCs and other myogenic cells differentiate into myofibroblasts, which produce collagen type I, the main component of fibrotic tissue, in the presence of this cytokine. Fibrosis can ultimately prevent patients from returning to their basic function, partly by preventing the formation of new axons towards myofibers, and contributes to a decrease in muscle contractility and range of movement. It is a known fact that as we get older, our cells gradually lose the ability to heal themselves and injury can cause muscle loss due to a process called muscular atrophy, which is where regenerative medicine takes place. Like stem cell injections, which fall under the category of stem cell therapy to treat or prevent a disease or condition by using stem cells. Stem cells are capable of differentiating into specific types of cells. The two defining features of a stem cell are perpetual s elf-regeneration and the ability to differentiate into a specialized type of adult cell. There are two main classes of stem cells: pluripotent cells that can become any cell in the adult body and multipotent cells that are limited to a smaller cell population. In the case of muscle damage, the cells that have been used most frequently in pre-clinical trials are muscle satellite cells (MSCs). MSCs have the ability to renew and differentiate into multiple lineages of connective tissue, including bone, fat, cartilage, tendon, muscle, and bone marrow stromal cells. Stem cell injections has proven to be successful in injured/aging mice but do to some challenges this form of therapy has not move forward to clinical trials, but results may forecast a promising future for regenerative medicine Research The research I found was limited to animal models and majority of the studies were performed in laboratory experiments on mice. For example, researchers at the Georgia Institute of Technology have developed a molecular matrix, a hydrogel, to deliver muscle satellite cells (MSCs) directly to damage muscle tissue in patients whose muscles do not regenerate well. The hydrogel was successfully in delivering MuSCs to injured, aged muscle tissue in mice and boosted the healing process while protecting the stem cells from harsh immune reactions. CS In Addition, the same method was also s uccessful in mice with a muscle tissue deficiency that matched Duchene muscular dystrophy, and if research progresses, the new hydrogel therapy could one day save the lives of people suffering from the disease. Researchers at the University of Colorado in Boulder and the University of Washington also discovered that stem cells injected into the muscles of the mouse led to an increase for the rest of the mouses life. The injuries not only healed, but muscle mass increased by 50 percent and muscle volume increased by 170 percent. For some reason, the stem cells did not simply multiply and replace old damaged cells. They formed new connections to myofibers and increased significantly in numbers within the muscle. In other words, whatever the transplanted stem cells did, it was much more than just repairing damage and normalizing things. Issues with Research When it comes to stem cell injections moving into clinical trials there are a few challenges that need to be faced for that to happen. For example our immune system, researchers at the Georgia institute for technology found that simply injecting additional muscle satellite cells into damaged, inflamed tissue was inefficient because the new cells enter the body when the immune system on the warpath. And like any muscle injury or disease its going to attract the immune system and where as in any other case this would be a good thing, in the case o f aged or dystrophic muscles it is not. This is because in this case the immune system release toxins that kill the stem cells off, in fact when tested the found that between and 1 and 20 percent of the injected MSCs actually made it to the targeted site and those that did were weakened. Which is why they developed a solution to coat the cells in , a hydrogel often start out as water-based solutions of molecular components that resemble crosses, and other components that make the ends of the crosses attach to each other. When the components come together, they fuse into molecular nets suspended in water, resulting in a material with the consistency of a gel. If stem cells or a drug are mixed into the solution, when the net, or matrix, forms, it ensnares the treatment for delivery and protects the payload from death or dissipation in the body. Whereas researchers at the University of Colorado at Boulder and the University of Washington ran into a different issue/ concern. The mice used in this experiment injuries were inflicted directly using barium chloride injections and its made the question if that was a natural injury or muscle loss due to a disease would the stem cell reaction be similar. And they also questioned if age at the time of injury/ treatment played a major role in the effects since they used mice that were about 3 months in age for the treatment and as donors. Sine the muscles in mice are very small so its unclear on how well the cells would migrate in the larger muscles of humans. Si milarities Mouse models are regarded as the most advanced and practical models used as an alternative to genetic research in humans. Ethical concerns in many cases prevent scientists from using human subjects and embryos to test stem cell therapies that could be used for future use. In such cases, it can be extremely useful that an impressive 99 percent of the genes belonging to mouse DNA match the corresponding human counterpart gene sequences. In this way, scientists can use embryonic and adult stem cells from mice and conduct their research unhindered while also gaining important insights into the potentially practical adaptation of research to clinical trials in humans. Mouse studies make stem cell research more bright than ever before. Many of the past few achievements and advances in embryonic stem cell research have been achieved using ES cells grown from different mouse models. Since embryonic cells can play a role in virtually any other cell type, mouse ES cells have already been used to develop and study different mouse tissue samples closely resembling human tissue and to evaluate their reaction to certain treatments and stimuli. The genetic manipulation of ES cells in the mouse and the addition of human genetic material are also at the forefront of e mbryonic stem cell research.